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Genetic portraits improve the chances of survival for cancer patients

Genetic portraits improve the chances of survival for cancer patients



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Treated patients live longer without additional health disadvantages
So-called genetic portraits of cancer patients can improve the probability of survival without the health condition deteriorating in this additional time. The identification of personalized therapy goals can be improved through the genetic images. Researchers found that a third of all patients treated experienced at least a 30 percent increase in progression-free survival.

The scientists from the Gustave Roussy Cancer Campus in France found in an investigation that the use of genetic portraits in cancer patients can massively increase the likelihood of survival. Many of the patients (about a third) lived longer without their condition worsening. The doctors publish the results of their study at the so-called Map (Molecular Analysis for Personalized Therapy) conference in London.

Does the analysis of the DNA from tumor samples lead to an improvement in treatment?
The aim of the new study was to determine whether an analysis of the DNA from tumor samples can really lead to an improvement in the treatment of cancer patients, the authors explain. For this purpose, the samples from more than 1,000 subjects with a wide range of disease types were analyzed. These diseases include, for example, lung, breast, head and neck, prostate, bladder, bowel and stomach cancer, the doctors add.

Gene sequencing is intended to make better therapeutic decisions
The DNA of the tumor could be sequenced through the collected samples. In this way, mutations can be found that may be better treated with special medicines, the researchers explain. The primary goal of the study was to enable better therapeutic decisions through gene sequencing. This improved form of treatment could improve survival in at least 25 percent of advanced metastatic cancer patients, explains study leader Professor Jean-Charles Soria from the Gustave Roussy Cancer Campus in Paris.

Treatment increases the likelihood of survival in 33 percent of patients
The final results showed that as many as 33 percent of patients are more likely to survive, the authors say. This is the first precise medical study to show the improvements in treatment options through DNA analysis in patients with advanced cancer.

Experimental drugs can slow tumor growth
The scientists also found that in some cases (one in five patients) experimental drugs can slow tumor growth in patients with advanced cancer. A target for treatment was found in the genes of 411 patients (about 49 percent of all samples provided). About half of these patients were then treated with so-called ADHOC therapy.

Affected people survived between five and 32 months longer
The improvement in survival was between five and 32 months. The time it took for tumors to grow back was compared to the results of previous treatments. "It is fantastic to see the efforts that are being made in this area of ​​research," the researchers emphasize. Now it is very important to get the best out of the data that has been collected up to the present time, the doctors explain further. (as)

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